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Moreover, the assays utilized in this study are developed for research purposes, limiting the generalizability of the results. However, this limitation also concerns most of the current TBI biomarker studies because there is a paucity of commercialized assays for clinical TBI diagnostics. The possibility of some degree of selection bias should be noted, as only a third of the patients treated at the recruiting hospital were eventually enrolled in the study. The current cohort is somewhat less severely injured than those in which the HCTS has been earlier validated. The HCTS was originally designed using a neurocritical care cohort https://pinupz.in/aviator.

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, 12 However, this is not common practice, which impacts the reproducibility and generalizability of these findings. 46

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The main limitation of the study is the variable delays between injuries and blood sampling. This may have affected biomarkers with a short half-life in blood, such as H-FABP, IL-10, and S100B. Furthermore, for NF-L, the sampling time-points might have been too close to the injury (64). Earlier mean sampling time would probably have resulted in different sensitivities and specificities for the panels.

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• The University of Bonn and Hauz Khas datasets did not have information regarding the number of seizures captured, so ictal segments were used in this case.
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• Although a minority of the screened patients were included in the current analyses, the patient selection did not introduce a significant bias, as the only difference was sex distribution.

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Appendix A

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• Comparison of AUCs by the model of DeLong and colleagues demonstrated a statistical difference in the discriminative ability of both Rotterdam and Helsinki scores when compared with Marshall’s classification.

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The biggest variation among the datasets surveyed is with regard to temporal properties, as shown in Table 3. Datasets are generally split into multiple segments with the same or different lengths in each segment. The length of each segment is determined by the authors and the limitations of the EEG recording devices. Datasets are split into two categories, continuous and noncontinuous datasets. Continuous datasets are further sub‐categorized as either long‐term (clinical) or short‐term continuous datasets, which can be seen in Table 3. Long‐term EEG continuous datasets consist of more than 24 hours of continuous recording with small time discontinuities in some cases, whereas short‐term EEG datasets contain recordings of less than 24 hours.

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Primary characteristics and structural properties of publicly available datasets. Primary characteristics of a dataset can be subdivided into 7 features (left), while structural properties consist of 3 features (right). The strengths of this study are the use of several biomarkers of different cellular origins in the same cohort, the use of sensitive advanced analytics, and a prospectively recruited well-characterized study population. Although a minority of the screened patients were included in the current analyses, the patient selection did not introduce a significant bias, as the only difference was sex distribution.

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• Hence, future seizure conjecture or detection research using the dataset should follow the particular instruction provided simply by the original research or documentations think about the channels required for seizure prediction or even detection tasks.
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• In terms of discriminating patients with complete and incomplete recovery, the three best individually performing biomarkers in outcome prediction were Aβ40, NF-L, and Aβ42 (Table 4).
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• This might cause confusion when comparing the datasets since some might consider seizure segments and seizure events as the same definition.

TBI is classically divided into mild, moderate, and severe based on the initial assessment using the Glasgow Coma Scale (GCS) score upon admission (5). The GCS score is one of the strongest clinical outcome predictors (3) but does not consider the complex pathophysiological characteristics of TBI. Furthermore, GCS assessment may be confounded by subjective interrater variability and patient’s intoxication or sedation (6, 7). No scheme or Aviator casino game strategy presented on the Internet can guarantee a 100% result. “Aviator” works on a random number generator, which does not allow you to calculate the aircraft takeoff algorithm. They help to systematize the game and control the level of costs.

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So, the dataset used for coaching and testing must include the exact same quantity of channels plus similar electrode positioning methods. One method to overcome this particular issue is in order to select datasets that will have an identical electrode placement along with a quantity of channels in this article the International 10–20 EEG placement. However, scientists and physicians need to get note that datasets that follow the similar electrode positioning method might nevertheless have a various quantity of channels along with additional electrodes or even channels to boost EEG resolutions. Hence, future seizure conjecture or detection research using the dataset should follow the particular instruction provided simply by the original research or documentations think about the channels required for seizure prediction or even detection tasks. Some of the datasets like the University associated with Bonn and Hauz Khas or personal datasets only consist of specific channels that will are less reflecting of real‐world ELEKTROENZEPHALOGRAPHIE data.

• The total seizure time for patients in each of the datasets was not calculated due to time constraints and the need to access and process each dataset.
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As discussed earlier, iEEG signals have a higher signal‐to‐noise ratio compared with surface EEG as they are less affected by artifacts and environmental factors. 1 , 29 Further, iEEG recordings are able to capture more epileptiform discharges compared with scalp recordings due to high signal attenuation by the skull from the source towards the scalp.